ZYRTEC® Clinical Data
ZYRTEC® provides consistent relief from seasonal allergic rhinitis (SAR) over a 2- to 4-week treatment period*1
Ocular Symptoms
Proven consistent relief of bothersome itchy, watery eyes in SAR patients through Week 12
- Improvement in Total Ocular Symptom Score (TOSS) during the first week of treatment†
- Large, multicenter study of 1255 seasonal allergy patients; most with moderate/severe symptoms based on a 4-point scale (0=none to 3=severe)
Relief of ocular symptoms continued over the 2-week treatment period†2
- 35% to 62% mean improvement from baseline in ocular scores†
Nasal Symptoms
Powerful relief of sneezing, runny nose, and itchy nose in SAR patients3
- Improvement in Total Nasal Symptom Score (TNSS) in the first week of treatment‡
- Large, multicenter study included 921 patients with SAR; most with moderate/severe symptoms based on a 4-point scale (0=none to 3=severe)
Significant improvement continued over the 2-week treatment period3
- 29% to 63% mean improvement from baseline in nasal severity scores‡
*All studies are multicenter, randomized, placebo-controlled, double-blind, minimum 100 participants with previous diagnosis of SAR, and adequate minimum duration (2 weeks). Total symptom severity score measured by patient.
†Randomized, placebo-controlled studies of SAR patients (N=1255). Total ocular symptom score (TOSS) was the sum of the severity scores for itchy eyes and watery eyes; one study also included red eyes. Individual symptom scores were rated on a 4-point scale (0=none to 3=severe). SAR 1 was 1 week in duration.
‡Randomized, placebo-controlled studies of SAR patients (N=921). Total Nasal Symptom Score (TNSS) was the sum of the severity scores for sneezing, runny nose, itchy nose in all studies; 2 studies included post-nasal discharge. Individual symptom scores were rated on a 4-point scale (0=none to 3=severe). SAR 1 was 1 week in duration.
References: 1. Data on file, Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division. 2. Patel M, Urdaneta E, Franklin K, et al. Cetirizine significantly relieves ocular allergy symptoms in subjects with seasonal allergic rhinitis. Poster Abstract. Data on file, Johnson & Johnson Consumer Inc., McNeil Consumer Health Division. 3. Urdaneta E, Tian X, Wu M, et al. Cetirizine effectively relieves both ocular allergy symptoms and nasal allergy symptoms in subjects with seasonal allergic rhinitis. Poster Abstract. Data on file, Johnson & Johnson Consumer Inc., McNeil Consumer Health Division.
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