Efficacy in Seasonal Allergies
The data says it all. ZYRTEC® provides powerful consistent relief of seasonal allergic rhinitis1—including bothersome ocular and nasal symptoms.2,3
Ocular symptoms
Proven relief of bothersome itchy, watery eyes2
- Improvement in Total Ocular Symptom Score (TOSS) during the first week of treatment†
- Large multicenter study of 1255 seasonal allergy patients, most with moderate/severe symptoms based on a 4-point scale (0=none to 3=severe)
- 35% to 62% mean improvement from baseline in ocular scores†
Nasal symptoms
Powerful relief of
sneezing, runny nose, and itchy nose3
- Improvement demonstrated in the first week of treatment‡
- Large multicenter study included 921 patients with SAR, most with moderate/severe symptoms based on a 4-point scale (0=none to 3=severe)
Significant improvement continued over the 2-week treatment period3 29% to 63% mean improvement from baseline in nasal severity scores‡
ZYRTEC® starts working at hour 1; Claritin® at hour 34,5§
A good reason to start with ZYRTEC®.
*All studies are multicenter, randomized, placebo-controlled, double-blind, minimum 100 participants with previous diagnosis of SAR, and adequate minimum duration (2 weeks). Total symptom severity score measured by patient.
†Randomized, placebo-controlled studies of SAR patients (N=1255). Total ocular symptom score (TOSS) was the sum of the severity scores for itchy eyes and watery eyes; one study also included red eyes. Individual symptom scores were rated on a 4-point scale (0=none to 3=severe). SAR 1 was 1 week in duration.
‡Randomized, placebo-controlled studies of SAR patients (N=921). Total Nasal Symptom Score (TNSS) was the sum of the severity scores for sneezing, runny nose, itchy nose in all studies; 2 studies included post-nasal discharge. Individual symptom scores were rated on a 4-point scale (0=none to 3=severe). SAR 1 was 1 week in duration. Changes from baseline over a 2-week period, by day in the first week, and weekly were assessed.
§ZYRTEC® 10 mg starts working at hour 1 and Claritin® starts working at hour 3, based on first dose on the first day of a 2-day study in 2 pollen-chamber studies. Primary endpoint measured mean improvement from baseline in Major Symptom Complex (MSC) severity score. MSC symptoms included runny nose, sniffles, itchy nose, nose blows, sneezes, and watery eyes.
References: 1. Data on file. Johnson & Johnson Consumer Inc., McNeil Consumer Health Division. 2. Patel M, Urdaneta E, Franklin K, et al. Cetirizine significantly relieves ocular allergy symptoms in subjects with seasonal allergic rhinitis. Poster Abstract. Data on file. Johnson & Johnson Consumer Inc., McNeil Consumer Health Division. 3. Urdaneta E, Tian X, Wu M, et al. Cetirizine effectively relieves both ocular allergy symptoms and nasal allergy symptoms in subjects with seasonal allergic rhinitis. Poster Abstract. Data on file. Johnson & Johnson Consumer Inc., McNeil Consumer Health Division. 4. Day JH, Briscoe M, Widlitz MD. Cetirizine, loratadine, or placebo in subjects with seasonal allergic rhinitis: effects after controlled ragweed pollen challenge in an environmental exposure unit. J Allergy Clin Immunol. 1998;101(5):638-645. 5. Day JH, Briscoe M, Rafeiro E, Chapman D, Kramer B. Comparative onset of action and symptom relief with cetirizine, loratadine, or placebo in an environmental exposure unit in subjects with seasonal allergic rhinitis: confirmation of a test system. Ann Allergy Asthma Immunol. 2001;87(6):474-481.